Researchers at UC San Diego have made a breakthrough in using engineered bacteria to improve metabolic health in mice. The study used metatranscriptomics to identify time-dependent microbial functions that can improve host metabolism. Mice given the engineered bacteria showed better blood sugar control, lower insulin levels, and increased lean mass. The next step is to test the bacteria in mice with obesity or diabetes caused by a high-fat diet. The researchers plan to explore other time-sensitive microbial genes to develop additional engineered bacteria that could improve metabolic health. The study’s findings demonstrate the potential for designing targeted microbial therapies based on functional insights. The researchers involved in the study have disclosed their affiliations and potential conflicts of interest with various biotechnology companies. The study’s results are promising and could lead to new treatments for metabolic disorders, such as diabetes and obesity. Further research is needed to confirm the efficacy of the engineered bacteria in disease models.
Uncovering the Internal Clock of Microbes Exposes a Novel Approach to Combating Metabolic Disorders
